Hereditary ATTR amyloidosis (hATTR) is an inherited disease (passed down through families) that often affects the nerves, heart and kidneys.1 hATTR amyloidosis is characterized by the deposit of an abnormal protein called amyloid in multiple organs of the body where it should not be, which causes disruption of organ tissue structure and function.2,3,4 In hereditary amyloidosis, amyloid deposits most often occur in tissues of the nervous system, heart, and digestive tract.1 About 50,000 people worldwide have hATTR amyloidosis.1
The first symptoms of hATTR amyloidosis typically appear between the mid-20s to the mid-60s, involve multiple tissues and organs and often seem unrelated. Because symptoms may be confused with more common conditions, hATTR amyloidosis can be hard to diagnose.5
1. Gertz MA. Am J Manag Care. 2017;23(7 suppl):S107-S112 2. Hawkins P et al. Ann Med. 2015; 47:625-638 3. Suhr O et al. J Int Med. 1994;235:479-485 4. Saraiva M. FEBS Letter. 2001;498:201-203 5. Amyloidosis Foundation. Understanding the patient voice in hereditary transthyretin-mediated amyloidosis (ATTR amyloidosis)